Smartox Biotechnology
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Smartox Biotechnology
離子通道研究用多肽毒素的專業(yè)化生產(chǎn)商
Smartox Biotechnology是全球**一家專門(mén)生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
Smartox Biotechnology于2009年由來(lái)自Grenoble神經(jīng)科學(xué)研究所(Grenoble Institute of Neuroscience)的Michel de waard博士創(chuàng)立,Smartox Biotechnology專門(mén)研究動(dòng)物毒液，制作合成多種毒液中的多肽成分（常稱為毒素）。De Waard博士研究離子通道與毒素多肽的關(guān)系，尤其是鑒定、開(kāi)發(fā)毒素多肽作為治療性分子或細(xì)胞穿透肽(cell penetrating peptides, CPP)。其研究團(tuán)隊(duì)在毒液分離，藥理性活性肽鑒定、富半胱氨酸肽定性、制作和優(yōu)化等方面具有獨(dú)特、豐富的經(jīng)驗(yàn)。2010年，Smartox Biotechnolgy被法國(guó)研究部(Ministry of Research)授予“新興企業(yè)OSEO獎(jiǎng)(OSEO prize for emerging businesses)”。
總之，Smartox Biotechnology提供一系列高質(zhì)量、具開(kāi)創(chuàng)價(jià)值的多肽毒素。這些化合物在離子通道 研究中具有高的親和性和選擇性，是相應(yīng)領(lǐng)域科學(xué)研究理想的生物毒素提供商和貼心的合作伙伴。
Smartox Biotechnology的毒素產(chǎn)品包括：
鈉離子通道(Sodium channel)
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Toxin name
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Catalog #
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Target
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Phrixotoxin-3
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13PHX003
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Selective blocker of Nav1.2
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μ-conotoxin GIIIB
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CON020
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Selective blocker of Nav1.4
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μ-conotoxin CnIIIC
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CON021
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Selective blocker of Nav1.4
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μ-conotoxin PIIIA
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08CON006
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Selective blocker of Nav1.4
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Jingzhaotoxin-III
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12JZH003
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Selective blocker of Nav1.5
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ProTx-II
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07PTX002
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Selective blocker of Nav1.7
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ProTx-II Biotin
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12PTB002
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Selective blocker of Nav1.7
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ProTx-I
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12PTX001
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Blocker of Nav1.8, Nav1.2, Nav1.5, Nav1.7
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Huwentoxin-I
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07HWT001
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Blocker of TTX-S
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Huwentoxin-IV
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08HWT002
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Blocker of TTX-S
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Hainantoxin-III
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13HTX003
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Blocker of TTX-S
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Hainantoxin-IV
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12HTX001
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Blocker of TTX-S
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GsAF-I
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12GSF001
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Blocker of TTX-S
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GsAF-II
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12GSF002
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Blocker of TTX-S
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鉀離子通道(Potassium channel)
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KCa channels
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Toxin name
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Catalog #
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Target
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Description
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Apamin
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08APA001
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SK1, SK2, SK3
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Charybdotoxin
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11CHA001
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KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6
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Iberiotoxin
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12IBX001
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KCa1.1
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Leiurotoxin 1 (Scyllatoxin)
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10LEI001
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SK1, SK2, SK3
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Tamapin
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10TAM001
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SK1, SK2, SK3
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Kaliotoxin-1
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08KTX002
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BK, Kv1.1, Kv1.2, Kv1.3
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Kv channels
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ShK
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08SHK001
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Kv1.3, Kv1.1, Kv1.4, Kv1.6
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TMR-ShK
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SAT001
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Kv1.3, Kv1.1
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Margatoxin
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08MAG001
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Kv1.3
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(Dap22)-ShK
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13SHD001
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Kv1.3
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ADWX-1
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13ADW001
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Kv1.3
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HsTx1
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08NEU001
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Kv1.3, Kv1.2
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Agitoxin-2
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13AGI002
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Kv1.3, Kv1.1
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Maurotoxin
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08MAR001
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Kv1.2, KCa3.1
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Guangxitoxin 1E
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11GUA002
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Kv2.1, Kv2.2
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Stromatoxin 1 NEW
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SCT01
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Kv2.1, Kv2.2
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Kaliotoxin-1
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08KTX002
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BK, Kv1.1, Kv1.2, Kv1.3
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Charybdotoxin
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11CHA001
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KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6
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Phrixotoxin-2
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PHX002
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Kv4.2, Kv4.3
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AmmTx3 NEW
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AMX001
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A-type potassium channels
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Inwardly rectifying potassium channels
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TertiapinQ
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08TER001
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Kir1.1, Kir3.1/3.4, Kir3.1/3.2-KCa1.1
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hERG/Kv11.1
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BeKm-1
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13BEK001
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ERG1
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鈣離子通道(Calcium channel)
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High voltage-gated Ca2+ channels
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Toxin name
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Catalog#
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Target
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Description
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ω-agatoxin IVA
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11AGA001
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P/Qtype
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ω-Conotoxin MVIIC
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08CON002
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P/Qtype, N-type
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ω-Conotoxin MVIIA
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08CON001
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N-type
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ω-Conotoxin GVIA
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08CON003
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N-type
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ω-Conotoxin SO3
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08CON013
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N-type
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Huwentoxin I
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07HWT001
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N-type
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ProTx-II
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07PTX002
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T-type, L-type
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Intermediate voltage-gated Ca2+ channels
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SNX482
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08SNX002
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R-type
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Low voltage-gated Ca2+ channels
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ProTx-I
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12PTX001
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T-type
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ProTx-II
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07PTX002
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T-type, L-type
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Ryanodine receptors
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Maurocalcine
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07PAU001
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Ryr1
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氯離子通道(Chloride channel)
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Toxin name
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Catalog #
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Target
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Description
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Chlorotoxin
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08CHL001
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Blocker of small conductance Cl- channels
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GaTx1
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13GTX001
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Selective blocker of CFTR channel
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GaTx2
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10GTX002
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Selective blocker of ClC-2 channel
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乙酰膽堿受體(Acetylcholine receptor)
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Toxin name
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Catalog #
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Target
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Description
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α-conotoxin PeIA
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13CON017
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α9α10, α3β2 subunits
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αC-Conotoxin PrXA
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13CON016
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α1/β1/ε/δ, α1/β1/γ/δ subunits
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Waglerin-1
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12WAG001
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MusclenAChR
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α-conotoxin MI
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08CON012
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α1/δsubunits
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α-conotoxin GI
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08CON005
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α/δsite
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α-conotoxin IMI
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08CON011
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α7 homomeric nAChR
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α-conotoxin GID
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CON019
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Blocker of α3β2, α7 and α4β2 nAChRs
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含N-甲基-D-天冬氨酸NR2B (NMDA, NR2B containing N-methyl-D-aspartate)
Conantokin-G選擇性、特異性抑制含NR2B的NMDAR。Conantokin-G能劑量依賴性抑制Ca2+內(nèi)流，抑制NMDA誘導(dǎo)的興奮性中毒效應(yīng)。研究表明，在小鼠皮層神經(jīng)元，Conantokin-G阻滯NMDA引發(fā)的電流信號(hào)的IC50值為480 nM。
酸敏感離子通道(ASIC channel, Acid-Sensing Ion Channel)
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Toxin name
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Catalog #
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Target
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Description
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APETx2
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07APE002
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Selective blocker of ASIC3
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Psalmotoxin1/PcTx1
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13PCT001
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Selective blocker of ASIC1a
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Ugr9-1
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13UGR001
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Blocker of ASIC3
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瞬時(shí)受體電位(TRP channel, transient receptor potential)
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Toxin name
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Catalog #
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Target
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Description
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GsMTx4
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08GSM001
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TRPC, TRPA
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Vanillotoxin3
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10VAN003
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Activator of TRPV1
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ProTx-I
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12PTX001
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Antagonist of TRPA1
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嘌呤能通道(Purinergic channel)
Purotoxin-1
選擇性抑制P2X3受體。100 nM Purotoxin-1 (PT-1)選擇性抑制P2X3受體通道，在大鼠DRG神經(jīng)元上，使用膜片鉗實(shí)驗(yàn)表明：PT-1對(duì)電壓門(mén)控通道和TRPV1均無(wú)抑制效應(yīng)。10 μM ATP和100 μM α,β Methylene-ATP濃度下Purotoxin-1對(duì)P2X3受體有選擇性作用，在該ATP濃度下Purotoxin-1對(duì)P2X2和雜化二聚體P2X2/3并無(wú)激動(dòng)作用。
Purotoxin-1對(duì)疼痛的潛在治療作用。
其它膜受體通道(Others)
Smartox Biotechnology還提供其他類型的膜受體抑制劑：
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Toxin name
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Catalog#
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Target
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Morphiceptin
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011CAS001
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Agonist of μ-opoid receptors
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Lys-conopressin G
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11CON14
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Vasopressin-like peptide
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GsMTx4
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08GSM001
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Mechano sensitive ion channels
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Obtustatin
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10OBT001
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Blocks the binding of α1β1 integrin to collagen IV
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Rho-Conotoxin TIA
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CON022
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Blocks α1-adrenergic receptor
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